The human body is composed of trillions of cells containing nearly identical genomes. However, the myriad of controlling factors that govern genomic regulation mean they can take on unique and distinct states and roles. Abnormalities in the genomes or the factors that control their behaviour can result in heterogeneity of cell populations and contribute to disease states. The maturation of single-cell technologies is making it increasingly possible to interrogate this heterogeneity and tease apart the resulting molecular mechanisms that drive disease phenotypes. This Forum will explore the latest research enabling single-cell genomics technologies and the impacts they are contributing in our understanding and treatment of disease

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